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Research Highlights

Researchers Alice Mac Donald and Dr. Delphine Guipouy from Dr. Elie Haddad's lab show that knocking down the KLRC1 gene, which encodes the inhibitory receptor NKG2A, improves NK cell anti-tumour activity against HLA-E+ tumours.

 Posted: April 15, 2024

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Alice Mac Donald (left), Dr. Delphine Guipouy (middle) and Dr. Elie Haddad (right)

Researchers Raghd Al Olabi and Dr Munir Rahim elucidate the role of the inhibitory NKR-P1B receptor interaction with C-type lectin-related protein-b (Clr-b) ligand in Natural Killer (NK) cell-mediated mammary tumour immunosurveillance in MMTV-PyVT mice. 

 Posted: December 21, 2023

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Raghd Al Olabi (left) and Dr. Munir Rahim (right)

Researchers Dr. Michal Scur and Dr. Andrew Makrigiannis demonstrate the importance of NKR-P1B and tissue-specific signaling in the immune reactivity of alveolar macrophages (AM) against pathogens, and in maintaining lung homeostatic mechanisms to prevent lipo-toxicity and cell death. 

 Posted: December 21, 2023

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Dr. Andrew Makrigiannis

Researchers Dr. Marie Marotel, Dr. Mohamed Shaad Hasim, and Dr. Michele Ardolino uncover a role for trogocytosis in tumor-mediated suppression of NK cells. 

 Posted: November 10, 2022

Dr. Marie Marotel (left) and Dr. Michele Ardolino (right)

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Researchers Lauren Westhaver and Dr. Jeanette Boudreau demonstrate that mitochondrial-derived damage-associated molecular patterns (mitoDAMPs) induce an immunoregulatory phenotype in T cells and Natural Killer cells in response to cellular damage.

 Posted: October 05, 2022

Lauren Westhaver (left) andDr. Jeanette Boudreau (right)

Researchers David Feehan and Dr. Christopher Mody demonstrate that NK cells facilitate bacterial killing against the extracellular pathogen, Pseudomonas aeruginosa, using a contact-dependent mechanism.

 Posted: August 25, 2022

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David Feehan (left) and Dr. Christopher Mody (right)

Researchers Dr. Laura Mathä and Dr. Fumio Takei demonstrate how the migration of Group 2 Innate Lymphoid cells from the lung to the liver link allergic lung inflammation and liver immunity.

 Posted: February 22, 2022


Dr. Fumio Takei (left) and Dr. Laura Mathä (right)

Researchers Sophie Poznanski and Dr. Ali Ashkar demonstrate that immune cell metabolism is a central factor in determining NK cell inhibition or cytotoxic function in the tumor microenvironment (TME).

 Posted: October 26, 2021

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Sophie Poznanski (left) and Dr. Ali Ashkar (right)

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 Posted: September 24, 2021

Researchers Dr. Abrar Khan, Saeedah Almutairi and Dr. Seung-Hwan Lee explore the mechanisms of NK cell metabolic reprogramming during MCMV infection in their recent Frontiers in Immunology publication.

Researchers Khlood Alsulami and Dr. Nicole Bernard analyze the link between NKG2C genotype and susceptibility and protection to HIV infection in recent Journal of Virology publication. 

 Posted: July 05, 2021

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Researchers Dr. Ning Wu, Hua Song, and Dr. André Veillette elucidate the mechanism by which NK cell lipid scrambling regulates NK cell activation and cytotoxicity in recent Cellular & Molecular Immunology publication. 

 Posted: April 27, 2021

Dr. Ning Wu (left) and Dr. André Veillette (right)

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