Dr. Sarah Crome
The Crome Lab is focused on exploring the role of Natural Killer (NK) cells and other innate lymphoid Cells (ILCs) in human immunology, transplantation, and immune tolerance. Along with other ILC family members, NK cells exhibit diverse and tissue specific functions that are impacted by perturbations in the microenvironments. Dysregulation of NK cell and ILC functions is associated with a breakdown in homeostasis, yet mechanisms behind this in humans remains largely unknown. Using multi-omic single cell techniques, humanized mouse models, as well as advanced immunoassays, our lab investigates NK cell and ILC biology and, how these cells are part of immunoregulatory networks in human health and disease. The ultimate goal being identifying novel therapies for autoimmunity, transplantation, and other pathologies.