NK cell fatty acid accumulation

At the Universite de Sherbrooke, we have observed accumulation of fatty acids in NK cells and this altered metabolism impairs their ability to clear tumors in the postoperative period.

3 comments

3 Comments

ashkara

Dec 11, 2018

Thanks Sophie for the post and thank you Michele and Lee for sharing. Michele: are you co-culturing NK cells with tumor cells?

mardolino

Dec 11, 2018

Replying to

Not yet, we plan to do that, but we need to characterize few cell lines first. Right now, we are mostly looking at NK cells in presence of several metabolites to determine the effect they have.

mardolino

Dec 04, 2018

Thanks for sharing Lee and awesome idea Sophie.

We are currently investigating how factors produced by tumor cells have an effect on NK cell metabolism.