At the Universite de Sherbrooke, we have observed accumulation of fatty acids in NK cells and this altered metabolism impairs their ability to clear tumors in the postoperative period.
Not yet, we plan to do that, but we need to characterize few cell lines first. Right now, we are mostly looking at NK cells in presence of several metabolites to determine the effect they have.
Thanks Sophie for the post and thank you Michele and Lee for sharing. Michele: are you co-culturing NK cells with tumor cells?
Thanks for sharing Lee and awesome idea Sophie.
We are currently investigating how factors produced by tumor cells have an effect on NK cell metabolism.